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| Registros recuperados : 3 | |
| Registros recuperados : 3 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
07/12/2021 |
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Data da última atualização: |
07/12/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
PIZAURO, L. J. L.; ALMEIDA, C. C. DE; SILVA, S. R.; MACINNES, J. I.; KROPINSKI, A. M.; ZAFALON, L. F.; AVILA, F. A. DE; VARANI, A. DE M. |
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Afiliação: |
LUCAS JOSÉ LUDUVERIO PIZAURO, UNESP; CAMILA CHIODA DE ALMEIDA, UNESP; SAURA RODRIGUES SILVA, UNESP; JANET I. MACINNES, UNIVERSITY OF GUELPH; ANDREW M. KROPINSKI, UNIVERSITY OF GUELPH; LUIZ FRANCISCO ZAFALON, CPPSE; FERNANDO ANTÔNIO DE AVILA, UNESP; ALESSANDRO DE MELLO VARANI, UNESP. |
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Título: |
Genomic comparisons and phylogenetic analysis of mastitis-related staphylococci with a focus on adhesion, bioflm, and related regulatory genes. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Scientific Reports, v.11, 2021, 17392. |
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Páginas: |
10 p. |
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DOI: |
https://doi.org/10.1038/s41598-021-96842-2 |
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Idioma: |
Inglês |
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Conteúdo: |
Mastitis is a common and costly disease on dairy farms, commonly caused by Staphylococcus spp. though the various species are associated with different clinical outcomes. In the current study, we performed genomic analyses to determine the prevalence of adhesion, biofilm, and related regulatory genes in 478 staphylococcal species isolated from clinical and subclinical mastitis cases deposited in public databases. The most prevalent adhesin genes (ebpS, atl, pls, sasH and sasF) were found in both clinical and subclinical isolates. However, the ebpS gene was absent in subclinical isolates of Staphylococcus arlettae, S. succinus, S. sciuri, S. equorun, S. galinarum, and S. saprophyticus. In contrast, the coa, eap, emp, efb, and vWbp genes were present more frequently in clinical (vs. subclincal) mastitis isolates and were highly correlated with the presence of the biofim operon (icaABCD) and its transcriptional regulator, icaR. Co-phylogenetic analyses suggested that many of these adhesins, biofilm, and associated regulatory genes could have been horizontally disseminated between clinical and subclinical isolates. Our results further suggest that several adhesins, biofilm, and related regulatory genes, which have been overlooked in previous studies, may be of use for virulence profiling of mastitis-related Staphylococcus strains or as potential targets for vaccine development. |
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Palavras-Chave: |
Biofim operon; IcaABCD; IcaR; Regulatory genes. |
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Thesaurus NAL: |
Adhesins; Mastitis; Staphylococcus; Staphylococcus arlettae; Staphylococcus equorum; Staphylococcus gallinarum; Staphylococcus saprophyticus; Staphylococcus sciuri; Staphylococcus succinus; Vaccine development. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/228590/1/GenomicComparisons.pdf
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Marc: |
LEADER 02607naa a2200397 a 4500
001 2137199
005 2021-12-07
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1038/s41598-021-96842-2$2DOI
100 1 $aPIZAURO, L. J. L.
245 $aGenomic comparisons and phylogenetic analysis of mastitis-related staphylococci with a focus on adhesion, bioflm, and related regulatory genes.$h[electronic resource]
260 $c2021
300 $a10 p.
520 $aMastitis is a common and costly disease on dairy farms, commonly caused by Staphylococcus spp. though the various species are associated with different clinical outcomes. In the current study, we performed genomic analyses to determine the prevalence of adhesion, biofilm, and related regulatory genes in 478 staphylococcal species isolated from clinical and subclinical mastitis cases deposited in public databases. The most prevalent adhesin genes (ebpS, atl, pls, sasH and sasF) were found in both clinical and subclinical isolates. However, the ebpS gene was absent in subclinical isolates of Staphylococcus arlettae, S. succinus, S. sciuri, S. equorun, S. galinarum, and S. saprophyticus. In contrast, the coa, eap, emp, efb, and vWbp genes were present more frequently in clinical (vs. subclincal) mastitis isolates and were highly correlated with the presence of the biofim operon (icaABCD) and its transcriptional regulator, icaR. Co-phylogenetic analyses suggested that many of these adhesins, biofilm, and associated regulatory genes could have been horizontally disseminated between clinical and subclinical isolates. Our results further suggest that several adhesins, biofilm, and related regulatory genes, which have been overlooked in previous studies, may be of use for virulence profiling of mastitis-related Staphylococcus strains or as potential targets for vaccine development.
650 $aAdhesins
650 $aMastitis
650 $aStaphylococcus
650 $aStaphylococcus arlettae
650 $aStaphylococcus equorum
650 $aStaphylococcus gallinarum
650 $aStaphylococcus saprophyticus
650 $aStaphylococcus sciuri
650 $aStaphylococcus succinus
650 $aVaccine development
653 $aBiofim operon
653 $aIcaABCD
653 $aIcaR
653 $aRegulatory genes
700 1 $aALMEIDA, C. C. DE
700 1 $aSILVA, S. R.
700 1 $aMACINNES, J. I.
700 1 $aKROPINSKI, A. M.
700 1 $aZAFALON, L. F.
700 1 $aAVILA, F. A. DE
700 1 $aVARANI, A. DE M.
773 $tScientific Reports$gv.11, 2021, 17392.
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Embrapa Pecuária Sudeste (CPPSE) |
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